Driven to Autoimmunity
نویسندگان
چکیده
منابع مشابه
Driven to Autoimmunity The Nod Mouse
In the lymphoid system, T cells respond to space or under-crowding by dividing to maintain their numbers. In this issue of Cell, evidence is provided that this homeostatic proliferation, coupled with excess production of a cytokine, IL-21, is a key factor in susceptibility to autoimmune diabetes.
متن کاملImmune to autoimmunity
he transcriptional state of a gene is connected to its association with the nuclear pore, according to Jason Casolari, Pamela Silver, and colleagues (Harvard Medical School, Boston, MA). Although the silencing of certain loci was known to rely on their localization to the nuclear periphery, where the pores lie, the new results suggest that yeast pores prefer transcriptionally active genes. “You...
متن کاملIL-12p35 subunit contributes to autoimmunity by limiting IL-27-driven regulatory responses.
Contrasting results have emerged from studies performed using IL-12p35(-/-) mice. Animals lacking the IL-12p35 subunit can either be protected from or develop exacerbated autoimmune diseases, intracellular infections, and delayed-type hypersensitivity responses. In this study, we report that mice lacking the IL-12p35 subunit develop a significantly milder Ag-induced arthritis compared with wild...
متن کاملLinking Retroelements to Autoimmunity
In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune response to self-nucleic acids. They show that the nuclease Trex1 prevents the accumulation of DNA derived from endogenous retroelements that, if left unchecked, trigger elevated production of type I interferons leading to autoimmunity.
متن کاملDirecting Autoimmunity to Nucleoprotein Particles
Over half a million people in the United States have sys-temic lupus. Most are women in their childbearing years. They usually have arthritis and scarring rashes, and about half have kidney involvement that may progress to renal failure. With time, there is an increasing likelihood that the brain will be involved, often resulting in loss of cognitive ability, seizures, and psychosis. Although t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell
سال: 2004
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(04)00340-x